Recognizing the destructive power of its captive giant Ape, the military makes its own battle-ready A.I., Mecha Ape but its first practical test goes horribly wrong, leaving the military no choice but to release the imprisoned giant ape to stop the colossal robot before it destroys downtown Chicago.

几十年前，苏联研制出杀不死的鲨鱼，并将它们送上月球。今天，一队美国宇航员将经历一场生死搏斗。

在第一部电影的事件之后，第二条牛鲨开始在德克萨斯州的一个湖泊中捕食毫无防备的受害者。