Creature of habit, Jon Smith, spends his days mindlessly working as a barista in New York City. When night falls, this seeming everyman savagely kills "filthy women" as his social outlet. A chance encounter with Delia, a young prostitute searching for an escape from her troubled past, forces Jon to confront the most terrifying thing he has ever faced in all his dark affairs - himself. All God's Creatures examines the true nature of what it means to be a monster and reveals that love is not only for a chosen few, but for all God's creatures.

杰米（米歇尔·波斯 Michelle Borth 饰）和雨果（卢克·科比 Luke Kirby 饰）是一对年轻的情侣，尽管在性生活上十分合拍，但出轨的阴影却始终笼罩在两人的关系上久久不能散去。凯蒂（艾利·沃克 Ally Walker 饰）和大卫（蒂姆·迪凯 Tim DeKay 饰）的情况刚好相反，深深相爱的两人愿意为了对方付出一切，却唯独无法满足彼此的性需求，两人平静的生活因此暗流汹涌。