Andy is a writer for newspaper classifieds who has been bouncing from relationship-to-relationship since sixth grade. Throughout the film, he loses custody of his dog when his girlfriend, Cheryl, breaks up with him for another man. Andy then meets Lorna, a children's TV show host, but she is too obsessed with her own dog to commit to a relationship with Andy. She's also still smiting because her boyfriend Trevor, left her for Andy's ex, Cheryl.　　Andy also has a fling with another woman, Keiran. Meanwhile, Cheryl takes Andy's dog to a psychiatrist, who tells her that her promiscuity is traumatizing the dog.

泰勒被迫藏匿一名受证人保护的女子的小女儿，这名女子将在联邦法院对哥伦比亚一个强大的贩毒集团作证，而两名冷酷无情的杀手正试图追捕她。

一名芝加哥警察退出警队并发现自己受到黑手党的威胁。