The Muppets are back in a new zany comedy, Muppets from Space. The Muppets embark on a hilarious extra terrestrial adventure in hopes of finding out about Gonzo's family members are aliens from a distant planet!　　Gonzo then gets a message that his relatives are coming for a visit, from outer space! But when word gets out on Miss Piggy's talk show, UFO Mania, that the friendly aliens are coming, a secret government agency led by K. Edgar Singer (Jeffrey Tambor) captures Gonzo and goes to great lengths to learn when his extra-terrestrial family will arrive.　　Now only the Muppets, led by Kermit and Miss Piggy, can save Gonzo and make the world safe for a friendly alien invasion!

贝丝和瑞秋是两姐妹，她们的生活截然不同。瑞秋是纽约市一位事业有成、干劲十足的时尚摄影师。贝丝则每天在她居住的美国东北部中型城市乘坐公交车。父亲去世后，瑞秋回到家中，与姐姐相聚，本应是一次短暂的探望。起初，这两个女人发生了争执：瑞秋试图……